Uji Penghambatan Tirosinase Dan Stabilitas Fisik Sediaan Krim Pemutih Yang Mengandung Ekstrak Kulit Batang Nangka (Artocarpus Heterophyllus)

The cortex of jackfruit (Artocarpus heterophyllus) contains some flavonoids which have activity as tyrosinase inhibitors. This compound can inhibit the oxidation of l-tyrosine and levodopa in the mechanism of melanogenesis. The extract of jackfruit cortex formulated into creams differentiated by the extract concentration of 1,5% and 2,0%. Physical stability test was conducted with storing the creams at three different temperatures, 7 ± 2°, 27 ± 2o, and 40±2oC respectively. Centrifugal tests and cycling test was also performed on both cream. Tyrosinase inhibitory activity measurement was done by in vitro studies with measuring dopachrome. The result showed that both of formulations which stored at 40±2oC and centrifugated at 3800 rpm for 5 hours were not stable. The result of tyrosinase inhibiton activity measurement of creams containing extract of 1,5% and 2,0 % were 10,64% and 11,34%, respectively. Tyrosinase inhibition activity of creams decreased after two month stored. Tyrosinase inhibition activity of cream containing 1,5%extract decreased into 6,93%, and cream containing 2,0%extract decreased into 7,74%. The decreasing of tyrosinase inhibition activity is caused by the small amount of antioxidant is not enough to prevent oxidation of active ingredient

A Common Software Configuration Management System for CERN SPS and LEP Accelerators and Technical Services

Software configuration management activities are crucial to assure the integrity of current operational and the quality of new software either being developed at CERN or outsourced. The functionality of the present management system became insufficient with large maintenance overheads. In order to improve our situation, a new software configuration management system has been set up. It is based on Razor, a commercial tool, which supports the management of file versions and operational software releases, along with integrated problem reporting capabilities. In addition to the basic tool functionality, automated procedures were custom made, for the installation and distribution of operational software. Policies were developed and applied over the software development life cycle to provide visibility and control. The system ensures that, at all times, the status and location of all deliverable versions are known, the state of shared objects is carefully controlled and unauthorised changes prevented. It provides a managed environment for software development, in various domains of the SPS and LEP CERN accelerators, and the technical services, automating code and lifecycle management. This paper outlines the reasons for selecting the chosen tool, the implementation of the system, the problems solved and the final goals achieved

Affine arithmetic-based methodology for energy hub operation-scheduling in the presence of data uncertainty

In this study, the role of self-validated computing for solving the energy hub-scheduling problem in the presence of multiple and heterogeneous sources of data uncertainties is explored and a new solution paradigm based on affine arithmetic is conceptualised. The benefits deriving from the application of this methodology are analysed in details, and several numerical results are presented and discussed

The first year of the ST Operation Committee: is there a future ?

The main objective of the ST Operation Committee (STOC) was to develop a proactive and homogeneous service of operation that satisfies the needs of the service users. Furthermore, the role of the Technical Control Room (TCR) should have been developed to a unique and competent entry point for ST operation by bringing the operation teams closer together on a daily basis. Have these objectives been achieved and to what extend? Is there a future for this committee and what could it look like? What are the implications of the first year of work on ST operation as a whole? This paper answers these questions and gives recommendations how to make best use of the STOC for the ST partners and ST, respectively

Affordability of Water Service from Perspective of Water Security of Community in Bekasi District

Affordability of society towards the cost of water service contributes to the selection of water source they use. Non-fulfillment of affordability aspect in accordance with the policy Regulation No. 23/2006, causing at least two things: the reduction of social welfare and security threats to the quality of water consumed by public. The affordability is calculated based on the costs used to meet water needs and family incomes. The analysis results in Bekasi show that social income of  <Rp 3,000,000 both use piping and non-piping service, the burden of their monthly expenditure to meet the water needs above the standard set by the government amounted to 4% of family income. Keywords: Affordability, Water, Piping service, Non-piping service, Welfare DOI: 10.7176/JRDM/60-05 Publication date:October 31st 201

LHC Communication Infrastructure: Recommendations from the working group

The LHC Working Group for Communication Infrastructure (CIWG) was established in May 1999 with members from the accelerator sector, the LHC physics experiments, the general communication services, the technical services and other LHC working groups. It has spent a year collecting user requirements and at the same time explored and evaluated possible solutions appropriate to the LHC. A number of technical recommendations were agreed, and areas where more work is required were identified. The working group also put forward proposals for organizational changes needed to allow the design project to continue and to prepare for the installation and commissioning phase of the LHC communication infrastructure. This paper reports on the work done and explains the motivation behind the recommendations

Microparticle-mediated transfer of the viral receptors CAR and CD46, and the CFTR channel in a CHO cell model confers new functions to target cells

Cell microparticles (MPs) released in the extracellular milieu can embark plasma membrane and intracellular components which are specific of their cellular origin, and transfer them to target cells. The MP-mediated, cell-to-cell transfer of three human membrane glycoproteins of different degrees of complexity was investigated in the present study, using a CHO cell model system. We first tested the delivery of CAR and CD46, two monospanins which act as adenovirus receptors, to target CHO cells. CHO cells lack CAR and CD46, high affinity receptors for human adenovirus serotype 5 (HAdV5), and serotype 35 (HAdV35), respectively. We found that MPs derived from CHO cells (MP-donor cells) constitutively expressing CAR (MP-CAR) or CD46 (MP-CD46) were able to transfer CAR and CD46 to target CHO cells, and conferred selective permissiveness to HAdV5 and HAdV35. In addition, target CHO cells incubated with MP-CD46 acquired the CD46-associated function in complement regulation. We also explored the MP-mediated delivery of a dodecaspanin membrane glycoprotein, the CFTR to target CHO cells. CFTR functions as a chloride channel in human cells and is implicated in the genetic disease cystic fibrosis. Target CHO cells incubated with MPs produced by CHO cells constitutively expressing GFP-tagged CFTR (MP-GFP-CFTR) were found to gain a new cellular function, the chloride channel activity associated to CFTR. Time-course analysis of the appearance of GFP-CFTR in target cells suggested that MPs could achieve the delivery of CFTR to target cells via two mechanisms: the transfer of mature, membrane-inserted CFTR glycoprotein, and the transfer of CFTR-encoding mRNA. These results confirmed that cell-derived MPs represent a new class of promising therapeutic vehicles for the delivery of bioactive macromolecules, proteins or mRNAs, the latter exerting the desired therapeutic effect in target cells via de novo synthesis of their encoded proteins

Star formation losses due to tidal debris in `hierarchical' galaxy formation

Bottom-up hierarchical formation of dark matter haloes is not as monotonic as implicitly assumed in the Press-Schechter formalism: matter can be ejected into tidal tails, shells or low density `atmospheres'. The implications that the possible truncation of star formation in these tidal `debris' may have for observational galaxy statistics are examined here using the ArFus N-body plus semi-analytical galaxy modelling software. Upper and lower bounds on stellar losses implied by a given set of N-body simulation output data can be investigated by choice of the merging/identity criterion of haloes between successive N-body simulation output times. A median merging/identity criterion is defined and used to deduce an upper estimate of possible star formation and stellar population losses. A largest successor merging/identity criterion is defined to deduce an estimate which minimises stellar losses. In the N-body simulations studied, the debris losses are short range in length and temporary; maximum loss is around 16%. The induced losses for star formation and luminosity functions are strongest (losses of 10%-30%) for low luminosity galaxies and at intermediate redshifts (1 < z < 3). This upper bound on likely losses is smaller than present observational uncertainties. Hence, Press-Schechter based galaxy formation models are approximately valid despite ignoring loss of debris, provided that dwarf galaxy statistics are not under study.Comment: 17 pages, 14 figures, accepted for Astronomy & Astrophysic